No increase in mean C max values was observed in any group after 10 days of administration of tinzaparin. Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more. We considered hypertension, diabetes, and high cholesterol levels as possible biological mediators of the effect of BMI on stroke and therefore did not control for these factors in the primary analysis. Risk factors for subarachnoid hemorrhage in a longitudinal population study. To compare BMI measurements over the study period, we calculated a Spearman correlation coefficient comparing baseline BMI to BMIs from the 8-year follow-up and study-end questionnaires after excluding subjects with severe illnesses. We calculated the proportion of total stroke and stroke types directly standardized for age to evaluate the association of BMI and stroke severity.

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Increase in both pro-thrombotic and anti-thrombotic internationzl in obese premenopausal women: We calculated age-adjusted and multiple-adjusted hazard ratios as a measure of the relative risk for total including ischemic, hemorrhagic, and undefined stroke casesischemic, and hemorrhagic including intraparenchymal and subarachnoid hemorrhage stroke.

Weight, weight change, and coronary heart disease in women: Reference lists of retrieved reports were checked for additional articles.

In conclusion, this study demonstrates that overweight and obese men are at increased risk of total, ischemic, and hemorrhagic stroke. Get free access to newly published articles Create a personal account or inyernational in to: Additional adjustment for diabetes did not further reduce the relative risks. Purchase access Subscribe now.


Body mass index and thromboembolic stroke in nonsmoking men in older internattional age: Monitoring of tinzaparin in a ten day treatment dose in elderly patients [in French]. The mean weight of the individuals of each group was not reported. An explicit cutoff of CrCl signifying renal impairment was not chosen.

Body Mass Index and the Risk of Stroke in Men

See More About Nephrology Anticoagulation. However, the age-adjusted percentage of fatal intraparenchymal hemorrhages among obese men 8. Some of these had small sample sizes 910 and others did not classify stroke subtypes. Purchase access Subscribe now.

The AUC was similar for all 4 groups. Stroke severity for total and ischemic stroke was not associated with BMI. Copyright American Medical Association. Corresponding author and reprints: Sign in to customize your interests Sign in to your personal account.

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Purchase internatilnal Subscribe to the journal. Incidence of total, ischemic, and hemorrhagic stroke was measured by self-report and confirmed by medical record review. Our study has several strengths, including its large size, prospective design, and the relatively homogeneous nature of the cohort, which reduces confounding by several variables, including access to medical care, educational attainment, and socioeconomic status.


Create a personal account to register for email alerts with links to free full-text articles. In contrast, accumulation was not observed in a trial with the higher-molecular-weight agent tinzaparin.

Unfortunately, LMW heparins also have the disadvantage that they can accumulate in patients with renal failure and therefore have the potential to produce serious bleeding inteenational such patients.

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Sign in to download free article PDFs Sign in to access your subscriptions Sign in to your personal account. All studies included for review used chromogenic anti-Xa assays for determining plasma LMW heparin levels, which is the recommended method of the College of American Pathologists. The Copenhagen City Heart Internatioonal.

Mean systolic and diastolic blood pressures as well as prevalence of hypertension increased with increasing BMI. The MRS classifies stroke cases from 1 no residual symptoms to 6 fatal stroke. These findings were not changed with additional adjusted-for-hypertension.

Smoking, alcohol consumption, and age did not substantially modify the effect for total, ischemic, and hemorrhagic intenational. Heparin and low-molecular-weight heparin: Am J Public Health.